趋化因子是当今细胞因子研究领域的热点之一,它参与多种免疫及炎症反应,在感染、肿瘤的生长与转移、组织修复及创伤愈合等病理生理过程中发挥重要作用.
    C-C型趋化因子受体1（CCR1）主要在嗜酸粒细胞，Th2淋巴细胞，肥大细胞，支气管上皮细胞上表达.CCR1在肿瘤的生长与转移方面起到一定的作用。

    This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha （MIP1 alpha）, regulated on activation normal T expressed and secreted protein （RANTES）, monocyte chemoattractant protein 3 （MCP3）, and myeloid progenitor inhibitory factor 1 （MPIF1）. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. Also named as C C chemokine receptor type 1; C C CKR 1; CC CKR 1; CCR 1; CD 191; CD191; CD191 antigen; Chemokine （C-C motif） receptor 1; Chemokine C C motif receptor 1; CKR 1; CKR1; CMKBR 1; CMKBR1; CMKR 1; CMKR1; HM145; LD78 receptor; Macrophage inflammatory protein 1 alpha receptor; MIP 1alpha R; MIP1aR; RANTES R; RANTES receptor; SCYAR1.